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在结核病患者的接触者中预测严格的QuantiFERON-TB Gold Plus转换

Sheng-Wei Pan¹, Donald G Catanzaro², Marva Seifert³

¹Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

|August 14, 2023

概括

结核病 (TB) 患者的疾病严重程度与接触者中阳性QuantiFERON-TB Gold Plus (QFT-Plus) 测试有关. 特定的干扰素马反应预测了QFT-Plus转化,表明接触者的结核病感染风险.

科学领域:

传染性疾病传染性疾病
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

结核病 (TB) 仍然是一个重大的全球卫生挑战.
了解传播动态和早期感染标志物对于控制至关重要.
量子菲龙-结核黄金Plus (QFT-Plus) 是一种用于检测结核病感染的干扰素-释放试验 (IGRA).

研究的目的:

调查指数患者的结核病严重程度与他们接触者的QFT-Plus结果之间的关联.
在6-12个月的时间内,确定联系人中的QFT-Plus转化预测因素.
探索CD8反应在结核病感染检测中的作用.

主要方法:

一项队列研究从2018年到2021年招募了295名结核病患者和1051名接触者.
在基线,6个月和12个月进行了QFT-Plus测试.
强烈的CD8反应和严格的QFT-Plus转换是基于干扰素玛 (IFN-γ) 水平来定义的.

主要成果:

结核病患者的接触者具有较高的唾液涂抹负载 (>1+) 显示QFT-Plus阳性结果的可能性更高.
双边肺病患者的接触者更有可能表现出强烈的CD8反应.
在6-12个月的接触中,观察到9.7%的严格QFT-Plus转化率.
具体的基线TB1和TB2IFN-γ反应协同预测了严格转换的19倍增加的风险.

结论:

指数结核病患者的细菌负担和肺病程度与接触者的QFT-Plus阳性和CD8反应相关.
结核病1和TB2 IFN-γ反应是结核病接触者严格QFT-Plus转换的关键预测因素.
这些发现提高了对结核病传播和早期感染检测的理解.

关键词:

干扰素玛释放量测定试验量子FERON-TB 黄金加上黄金.强迫力转换强迫力转换结核病患者与接触者接触

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