血清铜水平与心血管疾病风险之间的关联:在PREDIMED试验中进行的一项嵌套病例对照研究
Carlos Muñoz-Bravo1, Pablo Olmedo2, Fernando Gil2
1Department of Public Health and Psychiatry, School of Medicine, University of Málaga, Málaga, Spain; Biomedical Research Institute of Malaga (IBIMA), Spain.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|August 14, 2023
概括
在参考范围内的高血清铜 (S-Cu) 水平与老年男性心血管疾病 (CVD) 风险增加有关. 这项研究表明,S-Cu与心血管疾病风险之间存在潜在的性别差异.
科学领域:
- 生物化学和心血管健康
- 微量元素新陈代谢和疾病风险
- 老年医学和公共卫生
背景情况:
- 微量元素与心血管疾病 (CVD) 风险有关.
- 血清铜 (S-Cu) 与心血管疾病的相关性需要进一步调查,特别是在风险人群中.
研究的目的:
- 调查血清铜水平与第一次心血管疾病 (CVD) 事件的风险之间的关系.
- 在高心血管风险的老年人群中评估这一关联.
主要方法:
- 在PREDIMED试验中进行的一项病例控制研究.
- 207例心血管疾病病例与436例对照病例进行了匹配.
- 使用感应合血质谱测量血清铜水平;使用多变量逻辑回归评估风险.
主要成果:
- 与对照组相比,在男性心血管疾病病例中观察到较高的平均血清铜水平 (1014.1比959.3μg/L,p=0.004).
- 在男性中,血清铜含量升高与心血管疾病风险增加2.36倍有关 (最高与最低四分位数).
- 在女性中没有发现显著的关联 (OR=0.43).
结论:
- 血清铜水平升高,即使在参考范围内,也与西班牙老年男性首次心血管疾病事件风险增加有关.
- 研究结果表明,血清铜与心血管风险之间的关系存在潜在的性别差异.
- 需要进一步的研究来证实这些性别差异,并阐明潜在的机制.
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