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菲洛邦:人类和模型生物体中骨细胞外基质蛋白的综合数据库
Margalida Fontcuberta-Rigo1, Miho Nakamura2,3,4, Pere Puigbò5,6,7
1Medicity Research Laboratory, Faculty of Medicine, University of Turku, Tykistökatu 6, 20520, Turku, Finland.
Bone research
|August 14, 2023
概括
Phylobone是一个新的数据库,详细介绍了31种物种的骨外细胞矩阵 (ECM) 蛋白质. 该资源通过揭示进化联系和潜在的药物点,帮助研究骨再生和骨质疏松症.
科学领域:
- 生物化学 生物化学
- 生物信息学是一种生物信息学.
- 进化生物学 进化生物学
背景情况:
- 骨细胞外基质 (ECM) 包含矿物质,原蛋白和非原蛋白,对骨结构和功能至关重要.
- 关于骨 ECM 蛋白质,它们的作用和物种变异的现有知识是不完整的,阻碍了骨再生和骨质疏松症等疾病的研究.
- 需要一个全面的资源来编目骨 ECM 蛋白质及其进化背景.
研究的目的:
- 创建最全面的骨外细胞矩阵 (ECM) 蛋白质数据库.
- 分析这些蛋白质的进化关系和功能领域.
- 确定潜在的模型生物和药物重新利用机会,用于与骨相关的研究.
主要方法:
- 开发了一个生物信息学管道,以识别和目录骨 ECM 蛋白质.
- 包括来自人类和30种脊椎动物的数据.
- 进行了进化关系分析,网络分析和功能域识别.
- 来自公共药物存储库的综合数据.
主要成果:
- 菲洛邦数据库包含来自31种脊椎动物的骨 ECM 的 255 种蛋白质.
- 确定了进化关系,促进了骨再生研究模型生物的选择.
- 在骨 ECM 蛋白中发现了高连接性,并确定了 214 个功能域,包括骨形成和再吸收的功能域.
- 发现了潜在的药物重用候选人.
结论:
- 菲洛本是研究骨 ECM 蛋白质的有价值,全面的资源.
- 该数据库通过提供进化见解来支持骨再生,骨质疏松症和机械生物学方面的研究.
- 有助于识别骨疾病的分子机制和新型治疗点.
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