休时间的屏幕时间对刺激性肠综合征风险的因果关系从孟德尔的随机化研究中得出的结论
Liesheng Lu1, Changqin Liu2, Kunpeng Liu3
1Department of General Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
Scientific reports
|August 14, 2023
概括
休时间的屏幕时间 (LST) 可能会因果性地增加刺激性肠综合征 (IBS) 的风险. 这项研究使用门德尔的随机化来分析来自100多万欧洲人的遗传数据,发现了显著的关联.
科学领域:
- 胃肠病学 胃肠病学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 休时间的久坐行为,特别是休时间的屏幕时间 (LST) 和易怒肠综合征 (IBS) 之间的关联已被观察到.
- 然而,LST和IBS之间的因果关系尚不清楚,需要进一步调查.
研究的目的:
- 通过两样本的门德尔随机化方法,研究休时间屏幕 (LST) 和易怒肠综合征 (IBS) 之间的潜在因果关系.
主要方法:
- 利用两个样本的门德尔随机化分析对来自1,190,502名欧洲个体的全基因组关联研究 (GWAS) 数据.
- 采用逆方差加权和加权中位数方法来评估因果关系.
- 进行了敏感性分析,包括MR-Egger,并通过删除可能混的单核酸多态 (SNP) 来验证发现.
主要成果:
- 反向差异加权和加权中位数分析表明,LST对IBS具有显著的因果作用 (OR = 1.120,95% CI 1.029-1.219和OR = 1.112,95% CI 1.000-1.236,分别).
- 灵敏度分析显示没有证据表明有质性 (MR-Egger,p = 0.139).
- 在删除混SNP和验证分析后的进一步分析支持了初步发现,加强了因果关系.
结论:
- 这项门德尔随机化研究提供了证据,支持休时间增加和易怒肠综合征的发展之间的潜在因果关系.
- 研究结果表明,减少休时间的屏幕时间可能是IBS预防或管理的潜在策略.
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