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内分泌作为高血压内皮功能障碍的标志物:系统性审查和元分析
Amir Hossein Behnoush1,2, Amirmohammad Khalaji3,4, Pegah Bahiraie5
1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
概括
增加的内分泌水平与高血压和内皮功能障碍 (ED) 有关. 这项研究表明,内分泌素可能是检测高血压患者ED的有用生物标志物,尽管需要进一步研究.
科学领域:
- 心血管医学 心血管医学
- 生物标志物研究 生物标志物研究
- 内皮细胞功能 内皮细胞功能
背景情况:
- 高血压是心血管疾病的主要全球风险因素.
- 内皮功能障碍 (ED) 通常在高血压发展之前.
- 恩多坎是一种与内皮功能障碍相关的新生物标志物.
研究的目的:
- 系统地审查和元分析内分泌水平与高血压之间的关联.
- 确定内分泌能否作为高血压患者内皮功能障碍的生物标志物.
主要方法:
- 在国际数据库 (PubMed,Scopus,Embase,Web of Science) 中进行系统搜索.
- 包括20项研究,共3130名参与者.
- 随机效应元分析以计算标准化平均差异 (SMD) 和95%置信区间 (CI).
主要成果:
- 与健康对照组相比,高血压患者的循环内分泌水平显著提高 (SMD 0.91,p < 0.01).
- 即使排除了伴随疾病或特殊人群的研究 (SMD 1.16,p < 0.01) 后,这种升高仍然存在.
结论:
- 在高血压患者中,循环内分泌水平显著升高.
- 恩多坎显示出作为一种易于测量的生物标志物,用于检测高血压中内皮功能障碍的潜力.
- 需要进一步的研究来证实endocan在这种情况下的实用性.
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