里瓦洛克萨班减弱了骨髓中中性粒细胞的成熟
R Schneckmann1, M Döring1, S Gerfer2
1Institute for Translational Pharmacology Düsseldorf, Medical Faculty, University Hospital of the Heinrich Heine University, Universitätsstr. 1, 40225, Düsseldorf, Germany.
Basic research in cardiology
|August 14, 2023
概括
里瓦洛克萨班通过阻碍中性粒细胞成熟而减少骨髓中的成熟白细胞. 这种效应仅限于恒温状态,可能有助于控制心脏损伤后的免疫反应.
科学领域:
- 血液学 血液学 血液学
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 作为XA因子抑制剂的里瓦罗克萨班可以提供心脏保护,并具有抗炎作用,但其对骨髓的影响尚不清楚.
- 骨髓激活对于心血管疾病 (CVD) 的发展和进展至关重要.
- 了解里瓦洛克萨班的BM效应对于阐明其在心血管疾病中的全部治疗潜力至关重要.
研究的目的:
- 为了研究里瓦洛克萨班在恒温条件下对骨髓组成的影响.
- 为了确定里瓦洛克萨班在心血管事件 (如缺血/反 (I/R) 损伤) 期间是否影响骨髓功能.
- 探索里瓦洛克萨班对ST升高心肌梗塞 (STEMI) 患者白细胞数的影响临床相关性.
主要方法:
- 鼠被用里瓦罗克萨班治疗了7天,以评估对骨髓平衡的影响.
- 用心脏缺血/反 (I/R) 损伤模型来评估rivaroxaban在模拟心血管事件中的影响.
- 分析包括骨髓细胞组成,白细胞分化标志物 (Spi1, Csfr1) 和循环白细胞计数.
- 接受里瓦洛克萨班治疗的ST升MI患者的临床数据分析了循环白细胞水平.
主要成果:
- 里瓦罗克萨班治疗减少了老鼠骨髓中的成熟白细胞,通过在原始细胞阶段阻止中性粒细胞的成熟.
- 这种对骨髓形成的抑制作用在恒温条件下观察到,但在I / R损伤 (紧急血液形成) 期间基本上被废除.
- 里瓦洛克萨班预治疗减少了心脏炎症和循环白细胞I / R后,STEMI患者在白细胞计数中表现出类似的减少.
结论:
- 里瓦洛克萨班在恒温条件下减弱骨髓中中性粒细胞的成熟.
- 里瓦洛克萨班的抗白细胞形成作用是短暂的,在心血管损伤后的紧急血液形成过程中克服.
- 这些发现表明,里瓦洛克萨班可能会在心脏事件 (如I/R损伤) 后限制过度的免疫反应.
相关概念视频
01:31Osteoclasts in Bone Remodeling
3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K
01:22Bone Marrow Sampling and Transplants
360
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
360