T细胞淋巴缺血与心肺旁路术后儿童感染风险增加有关
Wen-Juan Li1, Yong-Xuan Peng1, Li-Qing Zhao1
1Department of Pediatric Cardiology, Xinhua Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.
接受心肺旁路术 (CPB) 的儿童面临更高的感染风险. 术后CPB淋巴缺血和炎症性细胞因子的升高与儿科患者早期术后感染的增加有关.
科学领域:
- 儿科外科手术 儿科外科手术
- 免疫学 免疫学 免疫学
- 传染性疾病传染性疾病.
背景情况:
- 接受心肺旁路术 (CPB) 的儿童因免疫抑制而容易感染感染.
- 在患有先天性心脏病 (CHD) 的儿科患者中,早期识别CPB后的感染风险具有挑战性.
研究的目的:
- 调查CPB后的淋巴缺血和儿童早期术后感染之间的关联.
- 为了确定是否监测淋巴细胞亚种群可以预测CPB后的感染风险.
主要方法:
- 对41名接受CPB治疗的2岁以下儿童进行了回顾性分析.
- 对炎症性细胞因子 (IL-6,IL-8,IL-10,IL-1β,TNF-α),CRP,PCT和淋巴细胞亚群 (CD3+,CD4+,CD8+) 的测量.
- 9名感染者与32名未感染者之间的比较.
主要成果:
- 感染者表现出较高的炎症性细胞因子水平和较低的绝对淋巴细胞计数 (CD3+,CD4+,CD8+).
- 与升高的IL-10水平相关的T细胞损伤.
- CD3+,CD4+和CD8+T细胞的特定值预测了早期的术后感染.
结论:
- 在CPB后炎症性细胞因子的增加有助于T细胞淋巴缺血,增加婴儿和幼儿的感染风险.
- 监测T细胞淋巴缺血可能比CRP或PCT更有效地预测早期术后感染.
更多相关视频
08:44Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
12:58Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
Published on: May 10, 2017
相关概念视频
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Cardiomyopathy VII: Pre and Post Operative Nursing Management
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
