艾滋病毒状况对急性尾炎的影响:南非的一项回顾性研究
Reza Laäs1, Damian L Clarke2, Nicholas Dufourq3,4
1Department of Emergency Medicine, Nelson R Mandela, School of Medicine, University of KwaZulu-Natal, 719 Umbilo Rd, Umbilo, Berea, 4001, South Africa. RezaLaasEM@gmail.com.
人类免疫缺陷病毒 (HIV) 显著增加尾炎患者的死亡风险,特别是那些CD4计数较低的患者. 建议加强监测和艾滋病毒检测,以改善高患病率地区的风险分层.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 外科手术的结果
背景情况:
- 人类免疫缺陷病毒 (HIV) 是南非手术患者常见的并发症.
- 艾滋病毒对急性尾炎结果的影响尚未得到充分证实.
研究的目的:
- 确定艾滋病毒状态如何影响急性尾炎的表现,评估,管理和结果.
- 调查艾滋病毒阳性和尾炎相关死亡率之间的关联.
主要方法:
- 从2013年至2019年,对1096名尾炎患者 (艾滋病毒阳性和艾滋病毒阴性) 的回顾性图表审查.
- 分析患者表现,生化标志物,炎症标志物和手术内严重程度.
- 主要结局:存活到出院;次要结局:住院时间长,冲击指数和死亡率.
主要成果:
- 17.9%的尾炎患者是艾滋病毒阳性.
- 艾滋病毒阳性患者住院时间较长,中位数冲击指数 (OR 7.65) 更高.
- 艾滋病毒阳性与死亡率增加显著相关 (OR 9.56),特别是在CD4<200细胞/mm3.4的患者中.
结论:
- 艾滋病毒阳性患者,特别是CD4<200细胞/毫米3或不接受ART治疗的患者,面临由尾炎引起的死亡风险更高.
- 建议增加这些患者的术后监测.
- 在高患病率地区向未知病情的患者提供艾滋病毒检测可以改善风险分层.
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