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Updated: Jul 19, 2025

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
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单细胞多原子分析的胸细胞发育揭示了 CD4+ T 细胞和 CD8+ T 细胞谱系承诺的驱动因素

Zoë Steier1,2,3,4,5,6, Dominik A Aylard7, Laura L McIntyre7

  • 1University of California, Berkeley, Department of Bioengineering, Berkeley, CA, USA.

Nature immunology
|August 14, 2023
PubMed
概括

所有胸细胞都开始CD4+T细胞的发育,第二个信号波指定CD8+T细胞系. 一个TCR-calcineurin-NFAT-GATA3通路驱动CD4+T细胞命运,揭示了T细胞谱系承诺中的顺序选择.

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