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相关概念视频

Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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定义侵袭性前列腺癌:一个地理空间视角.

Daniel Wiese1,2, Tesla D DuBois3, Kristen A Sorice3

  • 1Department of Surveillance and Health Equity Science, American Cancer Society, 3380 Chastain Meadows Pkwy NW Suite 200, Kennesaw, GA, 30144, USA. daniel.wiese@cancer.org.

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概括
此摘要是机器生成的。

对侵袭性前列腺癌 (PCan) 的不同定义对干预的空间分析产生影响. 使用远程SEER总结阶段 (D2) 最好与PCan死亡率模式保持一致,为有针对性的公共卫生工作提供一致的方法.

关键词:
侵袭性前列腺癌是什么地理空间是什么意思前列腺癌是什么意思 前列腺癌是什么意思对生存分析的分析.

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科学领域:

  • 在瘤学瘤学.
  • 地理空间分析是什么
  • 公共卫生 公共卫生

背景情况:

  • 空间分析有助于识别需要干预的侵袭性前列腺癌 (PCan) 风险社区.
  • 对积极的PCan存在多种定义,这使得针对性的公共卫生工作变得复杂.
  • 本研究评估了三个积极的PCan定义及其与PCan特定死亡率相对的地理空间模式.

研究的目的:

  • 评估不同定义的侵袭性前列腺癌如何影响空间模式和干预目标.
  • 以PCan特定的死亡率数据比较来自三个不同的积极PCan定义的地理空间模式.
  • 提供在地理空间研究中选择适当的积极PCan定义的方法见解.

主要方法:

  • 利用了宾夕法尼亚州癌症登记数据 (2005-2015年).
  • 应用了三种对积极PCan的定义:D1 (T4/N1/M1或格里森≥8),D2 (远程SEER总结阶段) 和D3 (格里森≥7).
  • 采用贝叶斯空间模型和考克斯回归来识别和比较具有攻击性PCan和PCan特定死亡率的地理集群.

主要成果:

  • 根据定义,攻击性PCan集群的数量,位置和规模因定义而异.
  • 空间模式显示所有定义都重叠,但D2 (远程SEER总结阶段) 集群最接近PCan特定的死亡率集群.
  • 与基于TNM分阶段的定义相比,D2定义产生了更少的干预集群,并且对缺失的数据不那么敏感.

结论:

  • 对侵袭性前列腺癌的远程SEER总结阶段定义 (D2) 显示了与PCan特定死亡率模式的最强一致.
  • 在未来的地理空间研究中采用D2可以提高一致性,并实现跨研究的标准化比较.
  • 这种定义提供了一个更强大的,不太敏感的数据方法来识别前列腺癌干预的高风险人群.