在高压护理人员中,klotho和端粒生物学之间的关联
Ryan L Brown1, Elissa E Epel1, Jue Lin2
1Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA 94107, USA.
Aging
|August 14, 2023
概括
患有自闭症谱系障碍 (ASD) 的儿童母亲的较高压力与免疫细胞中klotho水平和端粒长度之间的关联有关. 这表明压力可能协调衰老的生物标志物.
科学领域:
- 老年病学和免疫学
- 衰老的生物标志物
- 压力和健康 压力和健康
背景情况:
- 已知衰老生物标志物,如klotho和端粒长度,随着年龄的增长而减少.
- 克洛托和端粒长度之间的关系,特别是在慢性压力条件下,仍然不太清楚.
- 克洛托是一种循环激素,参与调节胰岛素信号,酸盐平衡,氧化应激和炎症.
研究的目的:
- 研究特定免疫细胞类型中klotho水平和端粒长度之间的关联.
- 为了确定护理压力,特别是对于患有自闭症谱系障碍 (ASD) 的孩子,是否会影响这些衰老生物标志物之间的关系.
- 探讨在高压力条件下对衰老生物标志物的潜在协调监管.
主要方法:
- 178名母亲的横截面研究:90名患有自闭症儿童的母亲 (高压力组) 和88名神经类型儿童的母亲 (低压力组).
- 在外围血液单核细胞 (PBMCs) 中测量血清中克洛托水平和端粒长度,包括CD4+和CD8+CD28-T细胞.
- 对年龄和体重指数进行统计分析,以评估klotho和端粒长度之间的关联.
主要成果:
- 在患有自闭症儿童的高压母亲中,在PBMCs (特别是CD4+和CD8+CD28-T细胞) 中观察到klotho水平和端粒长度之间的积极关联.
- 在具有神经类型儿童的母亲的低压力组中,没有发现klotho和端粒长度之间的显著关联.
- 在任何评估的细胞类型或细胞组中,klotho水平和端粒酶活性之间没有发现显著的关联.
结论:
- 这些发现表明,更高的护理压力可能参与了klotho水平和端粒长度之间的关联.
- 结果表明,在高压力条件下,长寿因子,klotho和端粒长度的潜在协调下调.
- 这项研究强调了慢性压力对免疫细胞中关键衰老生物标志物之间的相互作用的影响.
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