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对UBE2C表达及其在肝细胞癌中的潜在作用和机制的全面分析

Xiao Li¹, Zhaosheng Ma², Linhang Mei²

¹Department of Emergency, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang 317000, China.

|August 14, 2023

概括

乌比基结合酶E2C (UBE2C) 在肝细胞癌 (HCC) 中过度表达,这是一种致命的癌症. UBE2C显示出作为HCC患者的诊断和预后生物标志物的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

肝细胞癌 (HCC) 是一种全球流行且致命的恶性瘤.
乌比奎丁结合酶E2C (UBE2C) 被认为是一种瘤基因,但其在HCC中的作用尚不清楚.
了解UBE2C在HCC中的表达,诊断,预后和机制作用至关重要.

研究的目的:

调查UBE2C在HCC中的表达水平.
评估UBE2C在HCC中的诊断和预后意义.
探索HCC中UBE2C的调节机制,包括促进子甲基化和上游微RNA.

主要方法:

在HCC中UBE2C表达的综合生物信息分析.
接收器操作特征 (ROC) 曲线和生存分析用于诊断和预后评估.
使用体外试验和生物信息学分析UBE2C促进体甲基化和上游微RNA相关性.

主要成果:

与正常对照组相比,UBE2C在HCC组织中显著上调.
UBE2C在HCC中表现出显著的诊断和预后价值.
在HCC中,UBE2C促进物甲基化降低,并且与UBE2CmRNA水平负相关.
hsa-miR-193b-3p被确定为HCC中UBE2C的潜在关键上游调节器.

结论:

在肝细胞癌中,UBE2C过度表达.
UBE2C 作为 HCC 的潜在诊断和预后生物标志物.
表观遗传修饰 (促进物甲基化) 和微RNA调节 (hsa-miR-193b-3p) 是影响HCC中UBE2C表达的关键机制.

关键词:

在 UBE2C 中,UBE2C 是诊断诊断诊断诊断诊断诊断肝细胞癌是肝细胞癌.肝癌肝癌是一种肝癌.微RNA (miRNA) 是一种微型RNA.预后预后预后

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