斯帕弗洛克萨辛与H2受体对抗剂的同时相互作用,降解和运动研究
- Shereen1, - Maria Qureshi1, - Iffat Sultana1
1Deparment of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan.
Pakistan journal of pharmaceutical sciences
|August 15, 2023
概括
斯帕弗洛克萨是一种抗微生物药物,可能与法莫蒂丁和拉尼蒂丁相互作用. 这些药物相互作用可能会影响sparfloxacin.
科学领域:
- 药理学 药理学是指药理学的学科.
- 分析化学 分析化学
- 微生物学 微生物学
背景情况:
- 斯帕弗洛克萨是一种具有广谱抗微生物活性的诺碳酸衍生物.
- 它在临床上用于治疗泌尿道,呼吸道和妇科感染.
研究的目的:
- 为了研究体中斯帕弗洛克萨和法莫蒂丁或拉尼蒂丁之间的药物相互作用.
- 开发和验证用于在这些药物的存在下测定斯帕弗洛克萨辛的光谱光度法.
主要方法:
- 开发了一种由两个组成部分组成的光谱光度测量方法来定量斯帕弗洛克萨.
- 在甲醇和甲醇:水混合物中进行了相互作用研究.
- 评估了与 famotidine/ranitidine 以及没有 famotidine/ranitidine 的 sparfloxacin 降解的动力学.
- 薄层染色学 (TLC) 用于识别降解产品.
主要成果:
- 建立了一种可重现的光谱法 (±5%可重现性) 用于斯帕弗洛克萨辛测定.
- 在 famotidine 或 ranitidine 的存在下,sparfloxacin 降解率降低.
- TLC分析证实了斯帕弗洛克萨降解产物的存在.
结论:
- 斯帕弗洛克萨辛和法莫蒂丁或拉尼蒂丁之间可能发生复杂性.
- 这些相互作用可能会影响sparfloxacin的生物可用性.
- 需要进一步的研究,以充分阐明临床影响.
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