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Updated: Jul 19, 2025

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酸脂混合囊泡具有刺激响应相分离,用于控制的膜功能

Avanashiappan Nandakumar1, Yoshihiro Ito1,2, Motoki Ueda1,2

  • 1Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan. motoki.ueda@riken.jp.

Chemical communications (Cambridge, England)
|August 15, 2023
PubMed
概括

与二硫化物结合的脂混合体形成囊泡,在减少时分离成不同的域. 这种膜相分离增强了被封装物质的温度控制释放.

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Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
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