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在全身正子发射断层扫描/计算机断层扫描上对多个标记物的生物分布和辐射剂量测量

Lianghua Li¹, Liangrong Wan¹, Haitao Zhao¹

¹Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Quantitative imaging in medicine and surgery

|August 15, 2023

概括

全身PET/CT动态扫描准确地绘制了F-FDG,Ga-PSMA-11和Ga-FAPI-04的生物分布. 这种先进的成像方法为这些放射性药物提供了精确的辐射剂量计算.

科学领域:

核医学就是核医学.
放射性药物科学放射性药物科学
医疗成像医学成像

背景情况:

[18F-FDG,[68Ga]Ga-PSMA-11和[68Ga]Ga-FAPI-04是临床上使用的标记物.
传统的短轴PET/CT限制了对这些辐射追踪器的全面成像.
需要全身生物分布和精确的辐射剂量评估.

研究的目的:

使用全身PET/CT动态扫描进行全身生物分布分析.
为了计算[¹⁸F]F-FDG,[⁶⁸Ga]Ga-PSMA-11和[⁶⁸Ga]Ga-FAPI-04.4的精确辐射剂量,我们使用了以下方法:
为了比较生物分布模式和三个标记物的有效剂量.

主要方法:

54名患者接受了全身PET/CT动态扫描,使用F-FDG,Ga-PSMA-11或Ga-FAPI-04.
在注射后进行了60分钟的动态扫描.
使用Pmod4.0和OLINDA/EXM软件对时间活动曲线 (TAC) 和辐射剂量计算进行定量分析.

主要成果:

在主要器官中观察到每个标记物的明显生物分布模式.
Ga-PSMA-11显示了肝脏,脏,肌肉,骨,心脏,胃,大脑,肺,脏和膀的特定吸收趋势.
平均有效剂量为[⁶⁸Ga]Ga-PSMA-11的1.47E-02 mSv/MBq,为[¹⁸F]F-FDG的2.52E-02 mSv/MBq,以及为[⁶⁸Ga]Ga-FAPI-04的2.23E-02 mSv/MBq.

结论:

[F]F-FDG,[68]Ga-PSMA-11和[68]Ga-FAPI-04表明它们具有有利的生物分布.
全身PET/CT动态扫描为准确的生物分布和剂量计算提供了一种高度有效的方法.
这种技术增强了对子标记放射性药物的评估.

关键词:

全身正子发射断层扫描/计算机断层扫描 (全身PET/CT)[18F]F-FDGG 的意思 [68Ga]Ga-FAPI-04 已经开始使用.[68Ga]Ga-PSMA-11 是一个可靠的测量器.生物分销生物分销剂量测量方法剂量测量方法

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