抗血管内皮生长因子治疗,或没有最初的类固醇治疗,用于支部视网膜静脉封闭的斑点
Hidetaka Noma1, Kanako Yasuda1, Ryota Nonaka1
1Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan.
Clinical ophthalmology (Auckland, N.Z.)
|August 15, 2023
概括
最初的类固醇注射与抗VEGF治疗相结合,可以减少分支视网膜静脉封闭 (BRVO) 黄斑胀的复发. 这种组合疗法增加了BRVO患者治疗之间的时间.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 血管疾病 血管疾病
背景情况:
- 分支视网膜静脉封闭 (BRVO) 可能导致黄斑胀.
- 类固醇注射可以抑制炎症因素并减少瘤复发.
- 抗血管内皮生长因子 (VEGF) 治疗是对黄斑的常见治疗方法.
研究的目的:
- 为了研究抗VEGF治疗的疗效与或没有初始类固醇注射治疗BRVO患者的黄斑胀.
- 为了比较两个治疗组之间的功能和形态结果和复发率.
主要方法:
- 这项研究涉及41只患有BRVO和黄斑的眼睛.
- 患者接受了单独的静脉内拉尼比祖马布注射 (IRI) 或下三氨 (STTA) 注射,随后进行IRI.
- 评估的水性幽默生物标志物,视力敏度,中央黄斑厚度 (CMT) 和水性耀斑值.
主要成果:
- 两组之间炎症生物标志物水平没有显著差异.
- 两组人都显著改善了视力敏度,CMT和水性耀斑值.
- 组合组具有显著更高比例的患者没有复发和更长的时间到最初的复发.
结论:
- 最初的STTA注射与IRI结合可能在管理BRVO黄斑瘤方面具有协同作用.
- 这种联合治疗可以增加抗VEGF治疗之间的间隔.
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