NAD(P) 跨酶异型分布提供了对复合体进化的洞察力
Annie Z Tremp1, Sadia Saeed1, Johannes T Dessens1
1Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom.
Frontiers in ecology and evolution
|August 15, 2023
概括
位于膜中的NAD(P) 转酶 (NTH) 在真核生物中广泛存在,但在植物中不存在. 它的分布和同型变异为基因进化提供了洞察力,特别是在猿类复杂系中.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 进化生物学 进化生物学
背景情况:
- 位于膜上的NAD(P) 转酶 (NTH) 促进NAD(H和NADP(H之间的可逆化物转移,加上质子转移.
- 在 prokaryotes 和 eukaryotes 中,NTH 结构性保存,局部化到细菌细胞质膜和动物线粒体内膜.
- 细胞NTH存在于两个具有非线粒体作用的异构体中,包括像*Plasmodium*这样的单细胞真核生物.
研究的目的:
- 在真核生物中系统地分析 * nth * 基因的流行率和同型分布.
- 研究不同真核细胞系中NTH的进化史和基因丢失模式.
主要方法:
- 生物信息学分析各种真核生物种群中的 * nth * 基因序列.
- 遗传学分析用于重建进化关系并识别基因丢失事件.
主要成果:
- 在大多数主要的真核细胞系中存在NTH,但有明显的例外,例如植物.
- 鉴定出异形分布模式,在不同群体之间存在显著差异.
- 在复杂系系中发现了明显的 * nth * 基因丢失场景的证据.
结论:
- 该研究提供了NTH分布和真核细胞进化的全面概述.
- 这些发现揭示了NTH的进化动态,包括复合体中特定的基因丢失事件.
- 这项研究有助于了解细胞中NTH的功能多样化和进化轨迹.
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