在孕期糖尿病中对第二季度甲状腺功能测试的评估:一个病例对照研究
Himsweta Srivastava1, Priyanka Mathe1, Nibedita Mondal2
1Department of Obstetrics and Gynaecology, University College of Medical Sciences, New Delhi, IND.
Cureus
|August 15, 2023
概括
妊娠期糖尿病 (GDM) 与甲状腺功能测试 (TFT) 的改变以及甲状腺过氧化酶抗体 (anti-TPO) 水平的升高有关. 对于有GDM风险的孕妇,建议进行常规的TFT查.
科学领域:
- 内分泌学 在内分泌学.
- 产科 产科 产科 产科 产科
- 免疫学 免疫学 免疫学
背景情况:
- 孕期糖尿病 (GDM) 是怀孕期间的葡萄糖不耐受,增加了母亲和婴儿并发症的风险.
- 怀孕早期母亲甲状腺功能变化与GDM风险有关.
- 怀孕期间的甲状腺功能低下会导致不良后果,包括流产,高血压和婴儿发育受损.
研究的目的:
- 为了比较甲状腺功能测试 (血清fT3,ft4,TSH) 和甲状腺过氧化酶抗体 (抗TPO) 在第二个三个月的GDM和非GDM孕妇之间的水平.
- 为了将不良妊娠结果与GDM和非GDM组的甲状腺功能测试相关联.
主要方法:
- 进行了一项嵌套病例对照研究,涉及350名孕妇 (怀孕13-28周).
- 40名GDM和40名非GDM妇女根据口服葡萄糖耐受性测试 (OGTT) 结果进行了选择.
- 甲状腺功能测试 (TFT) 和抗TPO抗体进行了比较;社会人口统计数据和怀孕结果进行了分析.
主要成果:
- 患有GDM的女性平均年龄大于非GDM女性.
- 与非GDM组相比,在GDM组中观察到明显较低的平均TFT值 (fT3,fT4,TSH).
- 在GDM组中发现了更高的抗TPO抗体水平,表明甲状腺自身免疫,这可能有助于胰岛素抵抗.
结论:
- 这项研究表明,甲状腺功能改变和GDM之间存在显著的关联.
- 虽然在GDM组中,多水和早产等母亲并发症更频繁,但没有达到统计学意义.
- 在GDM组中发现剖腹产的发病率较高,支持在高危妊娠中进行常规TFT查的建议.
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