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在原始反动物chevrotains中发现了内源性泡病毒

Xiaojing Wang^1,2, Jie Cui^1,3

¹CAS Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences , Shanghai, China.

Microbiology spectrum

|August 15, 2023

概括

研究人员在老鼠-鹿基因组中发现了一种新的古老的泡病毒 (FV),扩大了这些复杂的逆转录病毒的已知宿主,并暗示了过去的跨物种传播.

科学领域:

病毒学病毒学
进化生物学进化生物学
基因组学就是基因组学.

背景情况:

泡病毒 (FVs) 是复杂的逆转录病毒,以持久感染和与宿主共同进化而闻名.
在哺乳动物中,内生形式的FV很少见,只有少数物种被记录为它们的庇护所.
了解FV演变对于破译宿主病毒相互作用至关重要.

研究的目的:

在类动物基因组中识别和表征新型内源性泡病毒.
调查新发现的FVs的进化史和宿主病毒关系.
为了扩大已知的宿主范围的泡状病毒.

主要方法:

两种雪佛兰 (老鼠-鹿) 物种的基因组测序和分析.
对内源性泡病毒 (TraEFV) 序列的遗传学分析.
分子时钟约会以估计内源病毒的年龄.

主要成果:

在两种老鼠-鹿物种的基因组中发现了一种名为TraEFV的新型内源性FV.
遗传学分析揭示了复杂的进化模式,TraEFV与猫类FV聚集在一起,而不是牛或马类FV.
TraEFV存在于两种不同的血统,表明至少有两种古老的跨物种传播事件.
分子时钟估计,TraEFV的起源大约在2000万年前.

结论:

这项研究报告了在Artiodactyla (平脚类动物) 中发现的第一个内源性FV.
这些发现表明,古代FV可能具有更广泛的宿主范围,并且比以前认为的更频繁的跨物种传播.
这一发现丰富了泡状病毒的宿主分类学,并突出了病毒进化的动态性质.

关键词:

内源性泡病毒的存在.遗传学分析遗传学分析它们是逆转录病毒.病毒的演变病毒的演变

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