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Updated: Jul 19, 2025

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
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SPOP突变准前列腺癌中的STING1信号,并对PARP抑制剂诱导的增长抑制产生治疗脆弱性

Chuandong Geng1, Man-Chao Zhang1, Ganiraju C Manyam2

  • 1Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Clinical cancer research : an official journal of the American Association for Cancer Research
|August 15, 2023
PubMed
概括

前列腺癌中的斑点型POZ蛋白 (SPOP) 突变改变了STING信号,造成了脆弱性. PARP 抑制剂可以将这种信号转移到抗瘤反应中,从而改善治疗结果.

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