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在COVID-19中脑脊液细胞因子:审查和元分析

Lily Devlin¹, Grace Y Gombolay²

¹Emory University School of Medicine, Atlanta, GA, USA.

Journal of neurology

|August 15, 2023

概括

脑脊液 (CSF) 中细胞因子的升高与COVID-19患者的神经症状有关,即使在CSF中没有检测到病毒. 需要对这些细胞因子概况进行进一步的研究.

科学领域:

神经学神经学
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

在患有严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染的患者中观察到神经复杂症,导致冠状病毒疾病2019 (COVID-19).
细胞因子水平的变化与COVID-19患者经历的神经症状相关.

研究的目的:

审查和分析COVID-19诊断的患者脑脊液 (CSF) 中的细胞因子水平.

主要方法:

在PubMed上进行了系统的文献搜索,查找到2022年11月11日之前发表的相关研究.
纳入标准要求有活跃SARS-CoV-2感染的证据和可用的CSF细胞因子分析.

主要成果:

该审查包括28项研究,包括346名COVID-19患者和356名对照.
在CSF中,SARS-CoV-2 PCR仅在0.9%的患者中呈阳性.
与对照组相比,COVID-19患者的脑脊髓液中发现有37种不同的细胞因子升高,其中介质素-6 (IL-6) 和介质素-8 (IL-8) 是最频繁升高的.

结论:

在COVID-19患者的CSF中炎症性细胞因子水平升高是常见的,通常发生在没有可检测的SARS-CoV-2RNA的情况下.
这些发现表明,细胞因子在COVID-19中神经症状的发病过程中起着重要的作用.
进一步调查CSF细胞因子概况及其对COVID-19的神经症状的贡献是有必要的.

关键词:

在 COVID-19 疫情中,在CSF中,有细胞因子.冠状病毒-19 冠状病毒-19 在COVID-19中出现的神经症状.这就是SARS-CoV-2病毒.

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