肉酸减轻了大鼠中甲三甲酸诱导的肺纤维化:用皮尔芬尼进行的比较研究
Eman Abdalhameid1, Enas A Abd El-Haleim2, Rania M Abdelsalam2,3
1Department of Pharmacology and Toxicology, Egyptian Drug Authority (EDA), Giza, Egypt. Eman.Ahameid.Saad@gmail.com.
Naunyn-Schmiedeberg's archives of pharmacology
|August 15, 2023
概括
在老鼠中,酸预处理有效地预防了甲状腺酸诱导的肺纤维化. 这种天然化合物表现出与皮尔芬尼类似的保护作用,提供了潜在的预防疗法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 肺部病理学 肺部病理学
背景情况:
- 肺纤维化涉及过度痕,破坏肺架构和损害通风.
- 甲托雷克萨特可以诱导肺纤维化作为严重的副作用.
- 锡南酸正在研究其潜在的保护作用.
研究的目的:
- 为了评估肉酸对甲状腺酸诱导的肺纤维化的保护作用.
- 评估肉酸对氧化应激,炎症和纤维化标志物的影响.
主要方法:
- 鼠在14天内接受了酸 (50毫克/公斤/天) 或皮尔费尼 (50毫克/公斤/天).
- 甲托雷克萨特 (14 mg/kg) 于第5天和第12天进行.
- 肺组织分析了氧化应激,炎症媒介和纤维化指标.
主要成果:
- 肉酸显著防止了甲基甲酸诱导的组织病理性肺损伤.
- 它改善了氧化,炎症和纤维化的参数.
- 它的疗效与标准药物pirfenidone.com的疗效相当.
结论:
- 肉酸对甲醇引发的肺纤维化具有保护作用.
- 它作为一个有前途的预防辅助疗法.
- 酸可能有助于减轻甲醇的肺毒性.
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