在日本人口中,ABO血型/基因型与COVID-19之间的关联
Tatsuya Kusumoto1, Shotaro Chubachi2, Ho Namkoong3
1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Annals of hematology
|August 15, 2023
概括
在日本COVID-19患者中,A型血型的患病率较高,而O型血型的患病率较低. 血型AB独立地增加了严重疾病的风险.
科学领域:
- 免疫遗传学 免疫遗传学
- 流行病学 流行病学
- 基因组学就是基因组学.
背景情况:
- 之前的研究表明,2019年新冠病毒病 (COVID-19) 和 ABO 血型之间存在联系.
- 在日本人口中进行的大规模调查和ABO基因型的作用是有限的.
研究的目的:
- 在一个大型的日本队列中调查 ABO 血型/基因型和 COVID-19 之间的关联.
- 分析COVID-19患者的ABO类型和临床结果之间的相关性.
主要方法:
- 1790名日本COVID-19患者的回顾性队列研究.
- 患者DNA的全基因组关联研究 (GWAS).
- 在COVID-19患者和健康对照者之间比较ABO血型/基因型频率 (n=611).
主要成果:
- 与对照人群相比,在COVID-19患者中,A型血液明显更为普遍 (41.6%与36.8%对比),O型血型较少 (26.2%与30.8%对比).
- 基因型OO在COVID-19组中不太常见.
- 与血型O和基因型OO相比,血型AB (aOR=1.84) 和基因型AB分别是严重COVID-19的独立风险因素.
结论:
- 血型O似乎可以防止COVID-19感染.
- 血型A与COVID-19感染的风险增加有关.
- 血型AB是日本人口中严重的COVID-19结局的独立风险因素.
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