中度严重性SARS-CoV-2 (COVID-19) 影响眼睛缩指数:基于眼睛跟踪的研究
Alex O Trofimov1, Darya I Agarkova1, Kseniia A Trofimova1
1Department of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Advances in experimental medicine and biology
|August 15, 2023
概括
中度的COVID-19肺炎显著损害眼睛跟踪,表明大脑纤维损伤. 男人表现出更高的垂直眼动指标,而女性表现出更高的水平指标,揭示了神经影响的性别特异性差异.
科学领域:
- 神经学 神经学
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
背景情况:
- SARS-CoV-2 (COVID-19) 流行病突出显示大脑是急性和慢性损伤的主要目标.
- 虽然神经退行变化仍在调查中,但关于大脑纤维通道受损的大量数据已经存在.
- 移动眼睛跟踪技术为住院COVID-19患者评估此类损伤提供了一个有前途的工具.
研究的目的:
- 评估中度COVID-19肺炎 (三角洲变种) 患者大脑纤维通道的功能和结构损伤.
- 在COVID-19的急性阶段,识别眼睛跟踪指标的潜在性别特异性.
主要方法:
- 这是一项对84名中度COVID-19肺炎 (Delta变种) 患者和158名健康对照者的回顾性研究.
- 使用移动眼睛追踪器 (眼睛追踪器低速20) 来评估垂直和水平眼睛的合 (VVRx和HVRx).
- 眼睛相交度指数 (VRx) 被计算为左眼球和右眼球之间的角速度的运动相关系数.
主要成果:
- 与对照组相比,中度COVID-19肺炎患者的VVRx和HVRx显著降低 (p < 0.000001).
- 在男性中,VVRx值显著更高 (p = 0.019).
- 在女性中,HVRx值显著更高 (p < 0.0000001).
结论:
- 适度的COVID-19肺炎与显著的眼睛跟踪性能恶化有关,这表明大脑纤维通道的功能和结构性损伤 (p <0.05).
- 观察到的VVRx (男性较高) 和HVRx (女性较高) 的差异表明,针对COVID-19的不同性别特异的神经反应.
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