怀孕患者治疗冠状病毒疾病的不良事件 2019年治疗方法
Mark Simon1,2, Jennie Buchanan3,4, Jonathan Schimmel5
1Rocky Mountain Poison & Drug Safety, Denver Health & Hospital Authority, 1391 Speer Blvd, Unit 600, Denver, CO, 80204, USA. mark.simon@denverem.org.
概括
孕妇患者经历了COVID-19疗法的不良事件,包括肝酶升高和关于胎儿心脏模式. 需要进一步的研究来确认这些COVID-19治疗副作用的因果关系.
科学领域:
- 药物监督 药物监督 药物监督
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 传染性疾病 传染性疾病
背景情况:
- 孕妇面临的严重后果的高风险,从冠状病毒疾病2019 (COVID-19).
- 关于COVID-19治疗方法在孕妇群体中的安全性和有效性的数据有限.
- 这项研究解决了了解怀孕期间与COVID-19治疗相关的不良事件的需要.
研究的目的:
- 在接受COVID-19治疗的孕妇患者中描述不良事件 (AE).
- 分析从一个专注于COVID-19治疗的药物监测项目中报告的副作用.
主要方法:
- 使用一个案例系列设计,分析来自FDA ACMT COVID-19 ToxIC (FACT) 药监测项目的数据.
- 数据从2020年11月到2022年6月收集,包括17个参与站点.
- 抽象的信息包括患者的人口统计,治疗细节,临床信息,怀孕的具体情况和结果.
主要成果:
- 46名孕妇患者在接受COVID-19治疗后报告了AEs.
- 雷梅西维尔 (47.8%) 和卡西里维玛布/米德维玛布 (17.4%) 是最常见的药物.
- 常见的母体副作用包括血清氨酸转移酶升高 (26.1%),而非令人放心的胎儿心脏模式 (20.0%) 是最常见的胎儿AE.
结论:
- 病例系列确定了不良事件,如肝酶升高,孕产妇肌梗塞和与COVID-19治疗相关的非令人放心的胎儿心脏模式.
- 该研究强调了与这些治疗在孕妇患者中相关的潜在风险,包括新出现的剖腹产.
- 需要进一步调查,以确定COVID-19疗法与孕妇观察到的不良事件之间的确切因果关系.
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