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在严重的COVID-19中,系统性核囊抗原清除受损

Christian Bauer¹, Elisabeth Mack², Véronique Hefter³

¹Department of Gastroenterology, Endocrinology, Metabolism and Infectiology, University Hospital Marburg, Philipps University, Marburg, Germany.

Journal of medical virology

|August 15, 2023

概括

核体抗原 (NCP) 在重症监护病房 (ICU) 中超过40%的严重COVID-19患者中仍然可以检测到数周. 延迟的NCP清除与严重疾病有关,并可能作为危急疾病的生物标志物.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
临床医学临床医学

背景情况:

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 核体抗原 (NCP) 在冠状病毒疾病-2019 (COVID-19) 患者中可检测到.
了解NCP动力学对于阐明COVID-19疾病严重程度至关重要.

研究的目的:

在住院COVID-19患者中调查血清NCP的清除动力学.
为了将NCP清除与疾病严重程度,炎症,抗体反应和病毒PCR结果相关联.

主要方法:

在63名住院COVID-19患者中,使用酶相关免疫试验量化血清NCP水平.
根据临床结果,炎症标志物和SARS-CoV-2 PCR状态分析了数据.

主要成果:

在46.7%的重症监护室 (ICU) 患者中,高水平的NCP水平在诊断后的8天内持续存在.
在超过40%的严重COVID-19病例中,NCP清除显著延迟,与非ICU患者和PCR清除形成鲜明对比.
延迟抗原血症与重症监护需求相关,并与较高的S1特异性IgG水平有关.

结论:

在COVID-19诊断后8天后延迟的NCP抗原血是需要重症监护的患者的特征.
NCP抗原清除动力学可能作为预测COVID-19严重性的机械生物标志物.

关键词:

在 COVID-19 疫情中,艾丽莎·伊丽莎·伊丽莎这就是SARS-CoV-2病毒.生物标志物生物标志物核体抗原是一种抗原.

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