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Updated: Jul 19, 2025

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
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High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy

Published on: February 7, 2019

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单分子研究描述了p53四重分子与不同原生反应元素结合的动力机制

Johannes P Suwita1, Calvin K Voong1, Elina Ly1

  • 1Department of Biochemistry, University of Colorado Boulder, Boulder, CO, United States of America.

PloS one
|August 15, 2023
PubMed
概括

瘤抑制剂p53蛋白与DNA结合,作为一个四聚合物. 单分子研究揭示了动态结合机制和独特的动态群体,挑战了以前的p53-DNA相互作用模型.

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相关概念视频

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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