[偶发性垂体腺瘤的临床和进化特征:回顾性多中心研究]
Roxana A Damilano1,2, Natalia L Monteserin3,2, Carolina Fux Otta4,2
1Servicio de Endocrinología, Sanatorio Allende, Córdoba, Argentina.
Medicina
|August 15, 2023
概括
垂体附带瘤 (PIs) 很常见,其中许多很大,导致视力或荷尔蒙问题. 大多数非手术的PI保持稳定,但临床上有意义的病变很常见.
科学领域:
- 内分泌学 在内分泌学.
- 神经外科 神经外科
- 放射学 放射学是一门学科.
背景情况:
- 垂体附带瘤 (PIs) 是经常在对无关疾病的成像时发现的病变.
- 了解它们的临床和进化特征对于患者管理至关重要.
研究的目的:
- 分析患有垂体瘤的患者的临床和进化特征.
- 确定与病变大小和临床表现相关的因素.
主要方法:
- 进行了一项回顾性,描述性,横截面研究.
- 分析了科尔多瓦67名PI患者的数据.
主要成果:
- 诊断时的中位数年龄为44岁,67%是女性.
- 头痛是最初成像的最常见原因 (34%).
- 宏观偶发性瘤占58%,男性患有较大的病变. 显著的细胞外延伸 (30%) 和洞穴性鼻侵袭 (45%) 被注意到. 神经眼科妥协发生在21%的患者中. 年龄和瘤大小之间存在正相关性 (r=+0.31,p=0.001).
- 91%的患者是非功能性的,但21%的人呈现出荷尔蒙缺乏症. 26%的患者需要进行手术.
- 大多数非手术的PI在42个月的中位数随访期间保持稳定.
结论:
- 观察到高频率的宏观偶发性瘤,经常呈现视野缺陷和下垂体.
- 尽管大多数非手术病例稳定,但很大一部分PI具有临床意义.
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