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对精选的兽药残留物的稳定性研究,这些残留物被添加到不同食品的提取物中

Steven J Lehotay¹, Maïwenn Le Floch², Alan R Lightfield¹

¹U.S. Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, Wyndmoor, PA, USA.

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概括

在兽药药物分析中,分析物的稳定性至关重要. 大多数测试药物在冷藏或冷时稳定一个月,但β-乳酸在室温下迅速降解.

科学领域:

分析化学分析化学
食品安全食品安全
兽医药理学兽医药理学

背景情况:

分析剂的稳定性显著影响分析化学结果.
了解各种矩阵和储存条件中的药物稳定性对于准确的兽医药物残留分析至关重要.

研究的目的:

评估31种常见的兽医药物在水和复杂食品矩阵 (牛奶//肝,肌肉/蛋) 中的稳定性.
评估不同储存温度 (室内,冰箱,冷柜) 和样品制备方法对一个月的分析剂稳定性的影响.

主要方法:

液体染色学-质谱学 (LC-MS) 使用三重四极和高分辨率技术.
对31种在水和牛/母体中升至10-1000 ng/g的兽药药物的分析.
在室温,冷藏和冷温度下储存一个月后评估分析物的稳定性.

主要成果:

在所有测试条件下,有10种药物 (达诺素,恩罗素,佛罗芬尼科尔,弗卢本达,氧-弗卢本达,弗卢梅奎因,弗鲁尼辛,5-氧-弗鲁尼辛,林科米辛,梅洛西卡姆) 显示稳定结果 (≤20%的损失).
β-乳糖抗生素 (安皮西林,塞法列辛,克洛西林,青素G) 在室温下高度不稳定.
几种类抗生素在样本提取物中比在水中更稳定;冷储存一般可以接受一个月.

结论:

兽医药物的稳定性因药物类别,基质和储存条件而异.
建议将提取物冷藏和冷,以保持分析物的完整性至少一个月.
准确量化兽药残留物,需要在样本制备和储存过程中仔细考虑分析物的稳定性.

关键词:

兽医药物兽医药物兽医药物分析物的稳定性.牛和的组织.蛋蛋蛋蛋蛋牛奶牛奶牛奶牛奶废物残留分析废物残留分析

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