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Fangzhu Zhao1,2,3, Meng Yuan4, Celina Keating1,2,3

  • 1Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.

Science signaling
|August 15, 2023
PubMed
概括

科学家们设计了一种现有的抗体来中和SARS-CoV-2,在动物模型中提供保护. 这种抗体工程策略为开发针对新出现的病毒威胁的治疗方法提供了快速的方法.

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Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...