Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Solvents01:12

Solvents

64.7K
A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
A...
64.7K
Sample Preparation for Analysis: Advanced Techniques01:08

Sample Preparation for Analysis: Advanced Techniques

391
Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
391
Solution Formation02:16

Solution Formation

31.8K
There is no one solvent that can dissolve every type of solute. Some substances that readily dissolve in a certain solvent might be insoluble in a different solvent. A simple way to predict which substances dissolve in which solvent is the phrase "like dissolves like". This means that polar substances, such as salt and sugar, dissolve in a polar substance like water. In contrast, non-polar substances are more soluble in non-polar solvents such as carbon tetrachloride.
This selective...
31.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Sugar-Based Eutectic Systems Combined with Cyclodextrins for Enhanced Solubility of Carvedilol.

Molecules (Basel, Switzerland)·2026
Same author

Analysis of cytotoxicity and assessment of α-glucosidase enzyme activity and stability in betaine-based eutectic systems.

International journal of biological macromolecules·2025
Same author

A Systematic Review: Migration of Chemical Compounds from Plastic Material Containers in Food and Pharmaceutical Fields.

Journal of xenobiotics·2025
Same author

Thermophysical properties of eutectic mixtures composed by oleic acid and components of essential oils.

Food research international (Ottawa, Ont.)·2025
Same author

Exploring Ibuprofen-Menthol Eutectic Systems: Physicochemical Properties and Cytotoxicity for Pharmaceutical Applications.

Pharmaceutics·2025
Same author

Deep Eutectic Solvent Systems as Media for the Selective Extraction of Anti-Inflammatory Bioactive Agents.

Molecules (Basel, Switzerland)·2025

相关实验视频

Updated: Jul 19, 2025

Preparation of Binary and Ternary Deep Eutectic Systems
06:15

Preparation of Binary and Ternary Deep Eutectic Systems

Published on: October 31, 2019

12.0K

用于口服应用的基于糖的深溶解剂.

Laura Lomba1, Alejandra Polo1, Álvaro Werner1

  • 1Facultad de Ciencias de la Salud, Universidad San Jorge, Campus Universitario, Autov. A23 km 299, 50830, Villanueva de Gállego, Zaragoza, Spain.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
|August 15, 2023
PubMed
概括

深度修养系统 (DES) 显示出提高药物溶解性的前景. 含有胆化物和糖的DES提高了罗斯米德溶解度的4530倍,为难溶性药物提供了新的配方可能性.

关键词:
药品中的活性成分 药品中的活性成分深层欧性溶剂 深层欧性溶剂口服液体配方是一种口服液体配方.物理化学特性 物理化学特性风病学研究 风病学研究可溶性 溶解度 可溶性 溶解度

更多相关视频

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues
09:22

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Published on: March 9, 2021

6.6K
Preparation of Naringenin Solution for In Vivo Application
08:18

Preparation of Naringenin Solution for In Vivo Application

Published on: August 10, 2021

3.4K

相关实验视频

Last Updated: Jul 19, 2025

Preparation of Binary and Ternary Deep Eutectic Systems
06:15

Preparation of Binary and Ternary Deep Eutectic Systems

Published on: October 31, 2019

12.0K
Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues
09:22

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Published on: March 9, 2021

6.6K
Preparation of Naringenin Solution for In Vivo Application
08:18

Preparation of Naringenin Solution for In Vivo Application

Published on: August 10, 2021

3.4K

科学领域:

  • 制药科学 制药科学
  • 物理化学 物理化学

背景情况:

  • 药物的溶解性对于治疗疗效至关重要,但许多药物具有较差的水溶性和口服生物可用性.
  • 弱酸和弱,常见的药物类型,由于溶解度有限,经常会带来配方挑战.

研究的目的:

  • 调查深度修养系统 (DESs) 提高药物的水溶性的潜力.
  • 探索由胆化物和各种含水量不同的糖 (xylitol,果糖,葡萄糖,醇) 形成的DES.
  • 评估这些DES对咖啡因 (BCS I类) 和富洛西米德 (BCS IV类) 溶解度的影响.

主要方法:

  • 使用胆化物和糖 (xylitol,果糖,葡萄糖,酸盐) 用不同的水比例形成DES.
  • 描述DES的物理化学特性,包括密度,折射率和表面张力.
  • 开发的DES配方的风湿学研究.
  • 在准备好的DES中评估咖啡因和furosemide的可溶性.

主要成果:

  • 含水量较高的DES显示咖啡因溶解性更好,但不超过纯水.
  • 观察到furosemide溶解度的显著增加,特别是在含水量低的基于西利的DES中,达到4530倍的增强.
  • 对于DESs,确定了密度,折射率,表面张力和风质等物理化学性质.

结论:

  • 深度学系统提供了一种可行的策略,可以提高水溶性较差的药物的溶性.
  • 特定的DES配方,特别是那些涉及到西利托尔的配方,在罗塞米德溶解度上显示出显著的改善.
  • 这些发现表明,有可能开发新的液体药物配方,以挑战活性药物成分.