由乙基衍生而来的全方位基水凝作为可注射药物输送系统
Shu-Ya Wang1, Maryamgul Tohti2, Jia-Qi Zhang2
1Xinjiang Key Laboratory of Agricultural Chemistry and Biomaterials, College of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumchi 830052, Xinjiang, People's Republic of China; School of Bioengineering, Dalian University of Technology, Dalian 116024, Liaoning, People's Republic of China.
International journal of biological macromolecules
|August 15, 2023
概括
研究人员开发了一种新的可注射水凝,用于持续的药物输送. 这种以pectin为基础的水凝显示出极好的胀,pH响应,并有效地提供5-FU,同时是细胞兼容的.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 聚合物化学 聚合物化学
背景情况:
- 可以注射的水凝由于其生物相容性和3D网络结构,对持续的药物输送充满希望.
- 是一种天然的多糖,为开发先进的药物输送平台提供了潜力.
研究的目的:
- 开发和表征一种基于全果丁的新型可注射水凝系统,用于药物输送.
- 为了评估胀,pH响应,药物释放动力学和基于pectin的水凝的细胞相容性.
主要方法:
- 氧化丁 (OP) 和二甲基酸酸盐功能化丁 (Pec-ADH) 的合成.
- 通过乙水连接形成基于pectin的水凝.
- 使用1H NMR,FT-IR和SEM进行表征.
- 在不同pH值下对蒸水和PBS的胀行为进行评估.
- 在体外药物释放研究中,对5-甲 (5-FU) 进行了研究.
- 用L929细胞系进行细胞兼容性测试和针对MCF-7细胞系的抗癌疗效.
主要成果:
- 基于pectin的水凝呈现出高平衡膨胀率 (高达4306.65%).
- 水凝表现出显著的pH和盐反应性,在pH值较高时,胀减少.
- 持续释放的5-FU被观察到超过12小时,没有爆发释放.
- 水凝与L929细胞具有很高的细胞相容性,并强烈抑制MCF-7癌细胞.
结论:
- 由乙基酸衍生而来的全方位基水凝是一种可行的和有效的注射药物输送系统.
- 开发的水凝具有控制释放治疗剂的理想特性.
- 这种基于pectin的系统显示了癌症治疗应用的潜力.
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