精神病内类型:基因组特定的多基因风险评分分析.
Baihan Wang1,2, Haritz Irizar1,3, Johan H Thygesen1,4
1Department of Mental Health Neuroscience, Division of Psychiatry, University College London, London, UK.
Schizophrenia bulletin
|August 15, 2023
概括
精神分裂症的遗传风险与P300脑波幅的减少有关,这表明早期发育影响. 基因组的多基因分数有助于揭示精神病内基因型机制.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 内分类型提供了精神病和遗传因素之间的联系.
- 了解内分类型的生物机制至关重要,但仍然具有挑战性.
- 这项研究调查了对精神病内分类型的遗传贡献.
研究的目的:
- 识别精神病底层生物机制的内类型.
- 将多基因风险评分分为特定的基因组.
- 测试基因组特异性多基因风险得分和内基因类型之间的关联.
主要方法:
- 使用与大脑相关的基因组计算了精神分裂症和双相情感障碍的多基因风险评分.
- 在4506名参与者中生成了378个基因组特定的多基因风险评分.
- 评估了七种内分类型,并使用线性混合效应模型来测试关联.
主要成果:
- 减少的P300幅度与前脑区域化基因组 (P = 6 × 10-5) 中更高的精神分裂多原风险得分显著相关.
- 前脑区域化基因组解释了与全基因组得分相比,P300幅度 (R2 = 0.032) 的变异性更大.
- 这突出了一个特定的遗传途径,影响一个可观察到的内分类型.
结论:
- 降低P300幅度可能表明遗传变异影响早期大脑发育,增加精神分裂症风险.
- 基因组特定的多基因风险评分对于剖析精神病内基因型机制非常有价值.
- 结果为细胞和动物模型的实验验证提供了基础.
相关概念视频
Polygenic Traits
66.0K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
66.0K
Human Genetics
612
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
612
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
746
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
746
Genome-wide Association Studies-GWAS
13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.6K
Psychological and Sociocultural Causes of Schizophrenia
139
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
139
Epistasis Analysis
5.1K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
5.1K


