人类营养相关性和建议的维生素A5 / X和维生素A5 / X的营养指南
Torsten Bohn1, Julian Hellman-Regen2, Angel R de Lera3
1Nutrition Research Group, Department of Precision Health, Luxembourg Institute and Health, 1 A-B, Rue Thomas Edison, 1445, Strassen, Luxembourg.
已经确定了一种新的维生素A5/X途径,与维生素A1不同. 本次审查建议将维生素A5/X纳入饮食指南,以改善营养理解和调节.
科学领域:
- 营养科学 营养科学
- 生物化学 生物化学
- 内分泌学 在内分泌学.
背景情况:
- 目前的营养指南主要侧重于维生素A1 (视网醇) 和其补充维生素.
- 作为视网-X受体 (RXRs) 的内源配体,特定视网的作用,如9-cis-retinoic acid,一直在争论中.
- 最近的研究确定了9-cis-13,14-dihydroretinoic acid作为一种内源的RXR配体,并提出了一个营养前体.
研究的目的:
- 介绍和概念化维生素A5 / X / 维生素A5 / X路径.
- 将维生素A5 / X概念与已建立的维生素A1 / 维生素A1概念相平行,以饮食摄入.
- 审查有关维生素A5/X的生理和营养相关性的现有法规和知识差距.
主要方法:
- 关于维生素A代谢和视网体信号传递的现有研究的文献综述.
- 维生素A5/X途径与已知的维生素A途径相关的概念化.
- 对维生素A和相关化合物的现行国家和国际法规的分析.
主要成果:
- 确定了维生素A5/X途径的存在和意义,其中涉及9-cis-13,14-dihydroretinoic acid作为RXR连接体.
- 强调需要考虑维生素A5/X与维生素A1一起在营养上下文.
- 在当前研究和监管框架中发现了有关维生素A5/X的漏洞.
结论:
- 建议将维生素A5 / X / 维生素A5 / X概念纳入日常饮食摄入量的考虑.
- 强调需要适应营养法规,以涵盖新了解的维生素A5 / X途径.
- 呼吁进行进一步的研究,以充分阐明维生素A5/X的生理和营养影响.
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