冠状动脉导管治疗累积辐射暴露对肺癌死亡率的影响
Jin Liu1,2, Shiqun Chen1,2,3, Yang Zhou1,2
1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
BMC cancer
|August 15, 2023
概括
重复的冠状动脉导管 (CC) 将心血管疾病 (CVD) 患者暴露在辐射中. 多重CC手术显著增加了这一群体肺癌和整体死亡率的风险.
科学领域:
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 冠状动脉导管 (CC) 对于诊断和治疗心血管疾病 (CVD) 是必不可少的.
- 患有心血管疾病的患者经常接受多次CC手术,导致累积辐射暴露.
- 这种累积的辐射暴露是患癌症的潜在危险因素.
研究的目的:
- 研究CC手术累积辐射暴露与癌症特异性死亡率之间的关联.
- 评估CC手术数量与所有原因和心血管死亡率之间的关系.
- 评估与心血管疾病患者重复辐射暴露相关的长期健康风险.
主要方法:
- 在中国 (2007-2020年) 的心脏改善II (CIN-II) 队列 (NCT05050877) 的多中心,回顾性研究.
- 136,495名没有癌症的患者根据接受的CC手术数量进行了分层.
- 考克斯回归和细灰竞争风险模型分析了累积辐射和死亡结果之间的联系.
主要成果:
- 接受2次CC手术的患者与1次手术 (P < 0.001) 患者相比,肺癌死亡风险增加1.42倍.
- 接受3次或更多CC手术的患者患肺癌死亡率增加1.64倍 (P < 0.05).
- 增加的CC手术频率也与较高的全因和心血管死亡率有关,但与其他癌症类型无关.
结论:
- 很大一部分心血管疾病患者从CC手术中接受多次高剂量辐射.
- 从重复的CC手术中获得的累积辐射暴露与心血管疾病患者癌症死亡率的增加有关.
- 在CC手术期间尽量减少辐射暴露对于改善心血管疾病患者的长期结果至关重要.
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