精神性厌食症青少年焦虑的神经表现:一种多变量方法
René Seiger1, Nicco Reggente2, D S-Adnan Majid3
1General Adult Psychiatry and Health Systems, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Translational psychiatry
|August 15, 2023
概括
患有神经性厌食症的青少年对引起焦虑的词语表现出更一致的脑反应,特别是在前额叶区域. 焦虑的严重程度与这种神经反应的一致性相关,这表明有条件的大脑反应可能会维持这种疾病.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
背景情况:
- 神经性厌食症 (AN) 涉及低体重,对体重增加的恐惧,以及身体形象的扭曲.
- 焦虑,特别是关于食物,饮食,体重和身体形象的焦虑,可能会导致AN的发展和持续.
- 了解AN的神经反应模式对于治疗开发至关重要.
研究的目的:
- 调查与对照组相比,患有AN的女性青少年的神经反应模式和一致性.
- 探索焦虑严重程度与神经反应一致性在AN之间的关系.
主要方法:
- 功能磁共振成像 (fMRI) 用于25名患有AN的女性青少年和22名患有轻度焦虑的非临床对照.
- 参与者在两个会议中观看了个性化的令人焦虑和中性词语刺激.
- 多变量表示相似性分析 (RSA) 和voxel-wise搜索灯分析评估了焦虑电路和整个大脑中的大脑反应一致性.
主要成果:
- 该AN组表现出更高的代表性相似性引起焦虑与中性刺激,主要在前额区域.
- 没有发现代表性相似性的显著群体差异.
- 焦虑的严重程度与各种皮质和皮质下区域的大脑反应的一致性呈正相关性,包括额头极,丘脑和小脑.
结论:
- 在焦虑严重程度较高的个体中,神经激活的更高的一致性表明对个人相关的情绪刺激有条件的反应.
- 焦虑引起的刺激可能会触发刻板的神经反应,可能有助于维持AN.
- 这些发现提供了关于AN中对环境线索的自动响应的见解.
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