慢性炎症与BMI之间的关系的门效应和性别特征
Su Liqiang1, Li Fang-Hui2, Quan Minghui3
1Physical Education College, Jiangxi Normal University, Nanchang, 330022, Jiangxi, China.
BMC endocrine disorders
|August 15, 2023
概括
身体质量指数 (BMI) 对慢性炎症具有值效应,超过24.3的水平显示出正相关性. 这种炎症效应在女性中比男性更为明显,特别是BMI超过33的女性.
科学领域:
- 生物医学科学 生物医学科学
- 公共卫生 公共卫生
- 炎症研究 炎症研究
背景情况:
- 慢性炎症是肥胖对健康产生负面影响的关键途径.
- 与肥胖相关的慢性炎症的增加通常无症状发生.
- 身体质量指数 (BMI) 与慢性炎症密切相关,作为预测因素.
研究的目的:
- 研究BMI对慢性炎症的值效应.
- 探索BMI和慢性炎症之间的关系中的性别特异性差异.
- 为了确定慢性炎症的影响是否在不同的BMI间隔内有所不同.
主要方法:
- 横截面研究涉及正常体重,超重和肥胖类别的个人.
- 测量BMI,高灵敏性C反应蛋白 (hs-CRP),阿迪波内克丁和虹膜蛋白.
- 应用多重回归分析和通用添加模型来分析hs-CRP和BMI之间的关联.
主要成果:
- 在调整年龄和性别后,发现BMI和hs-CRP (β=0.45,P<0.001) 之间存在显著的积极关联.
- 观察到一个值效应:BMI>24.6与hs-CRP正相关 (β=0.54,P<0.001),而BMI18.5-25.4没有 (β=-0.02,P>0.05).
- 增加的BMI的促炎效应在女性 (β=0.56,P<0.001) 中比在男性 (β=0.38,P<0.001) 中更大.
结论:
- 体重指数 (BMI) 对慢性炎症具有值效应,在体重指数 (BMI) 超过24.3.3时,出现正相关性.
- 没有发现BMI (18.5-24.3) 和慢性炎症之间的相关性.
- 高BMI的炎症影响在女性中明显高于男性,特别是当BMI超过33时.
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