TERT rs2736100 (A > C) 多态和肺癌风险之间的种族特异性关联:全面的元分析
Xiaozheng Wu1, Gao Huang1, Wen Li1
1Department of Preclinical Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, 510025, China.
Scientific reports
|August 15, 2023
概括
TERT rs2736100 C等位基因增加了肺癌的风险,特别是在亚洲人中. 这种遗传因素有助于各种类型的肺癌,种族和吸烟状况影响了易感性.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- TERT rs2736100多态性与肺癌 (LC) 风险有关,但研究结果不一致.
- 澄清这种跨不同种族和LC亚型的关联至关重要.
研究的目的:
- 对全基因组关联研究 (GWAS) 和病例控制研究进行元分析.
- 为了确定TERT rs2736100多态和LC敏感性之间的关联.
- 调查这一协会中的种族和LC亚型特定差异.
主要方法:
- 在PubMed,EMbase,CENTRAL和MEDLINE数据库进行系统的文献搜索,截至2022年5月7日.
- 使用Revman5.3进行数据提取,森林地块和漏斗地块的元分析.
- 使用Stata 12.0.0进行的敏感性和出版偏差分析.
主要成果:
- TERT rs2736100 C等位基因与LC风险总体增加有关 (OR=1.21) 和高加索人 (OR=1.11) 和亚洲人 (OR=1.26),亚洲人的风险更高.
- 在所有人群中,C等位基因与非小细胞肺癌 (NSCLC) 和肺腺癌 (LUAD) 的风险有关,在亚洲人群中与肺状细胞癌 (LUSC) 和小细胞肺癌 (SCLC) 的风险有关.
- 吸烟状态没有显著改变TERT rs2736100与LC风险的关联,这表明多因素的病因.
结论:
- TERT rs2736100 C等位基因是LC,NSCLC和LUAD的重要风险因素,特别是在亚洲人群中.
- 对于与这种多态性相关的LUSC和SCLC风险存在种族差异.
- 肺癌的发展受到遗传,环境和生活方式因素的复杂相互作用的影响.
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