功能连接的改变尽管在急性缺氧期间保留了大脑氧化
Marleen E Bakker1,2, Ismaël Djerourou3, Samuel Belanger4
1École d'Optométrie, Université de Montréal, 2500 Chem. De Polytechnique, Montréal, QC, H3T 1J4, Canada. marleen.bakker@polymtl.ca.
Scientific reports
|August 15, 2023
概括
急性全球缺氧改变了大脑的连接. 虽然血液氧化和神经元活动最初发生变化,但它们会恢复到基线. 然而,静止状态网络显示前后连接性下降,这表明神经血管脱.
科学领域:
- 神经科学是一个神经科学.
- 生理学 生理学 生理学
- 脑部成像 脑部成像
背景情况:
- 休息状态网络 (RSN) 对于在没有外部刺激的情况下了解大脑功能至关重要.
- 在缺氧等生理挑战期间评估大脑网络的变化至关重要.
研究的目的:
- 研究急性全球缺氧期间静态网络 (RSN) 和血液动力学反应的变化.
- 在低氧条件下探索潜在的神经血管脱.
主要方法:
- 同时使用GCaMP和内在光学成像在不同氧气水平 (21%至8%) 的小鼠中.
- 神经活动和血液动力学变化 (HbO,HbR) 被追踪了10周,间隔与normoxia.
- 使用GCaMP和HbO测量分析了静止状态网络连接.
主要成果:
- 在缺氧期间观察到的HbO和HbR的全球增加.
- 血氧和 (sO2) 和神经元活动在缺氧发作时达到峰值,但恢复到基线.
- 通过GCaMP测量的前后RSN连接性下降与通过HbO增加的连接性形成对比,表明潜在的神经血管脱.
结论:
- 尽管恢复到基线的sO2水平,但低氧会诱导神经元静止状态网络的持久变化.
- 观察到神经元和血液动力学连接之间的差异表明在急性全球缺氧期间的神经血管脱.
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