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多基因对气球模拟风险任务绩效的贡献

E L Nurmi¹, C P Laughlin², H de Wit³

¹Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA, 90024, USA. enurmi@g.ucla.edu.

Molecular psychiatry

|August 15, 2023

概括

这项研究使用气球模拟风险任务 (BART) 探索了风险决策的遗传基础. 研究结果揭示了冒险行为的多基因架构及其与大麻使用的关联.

科学领域:

神经科学是一个神经科学.
行为遗传学行为遗传学
精神病学遗传学精神病学遗传学

背景情况:

风险决策是一种遗传性特征,在精神疾病中观察到.
风险决策的遗传基础在很大程度上仍未被探索.
气球模拟风险任务 (BART) 是一种经过验证的风险决策行为的衡量标准.

研究的目的:

通过BART测量,研究风险决策的遗传架构.
为了识别与BART性能相关的遗传变异.
探索风险决策和精神病现象之间的遗传重叠.

主要方法:

两个独立的欧洲血统样本进行了BART.
构建了多基因风险评分 (PRS) 并对其复制进行了测试.
一项全基因组MEGA分析将样本组合起来,以测试与自我报告措施和精神病诊断的遗传相关性.

主要成果:

在复制样本 (r=0.13,p=1.2e-5) 中,PRS对BART性能预测任务性能.
在IGSF21附近确定了一个全基因组显著的SNP (rs12023073),需要复制.
对于大麻使用的PRS,但不是自我报告的风险承担或精神疾病状态,预测了BART行为.

结论:

根据BART的评估,风险决策表现出一种多基因架构.
影响BART表现的遗传因素与影响大麻使用的遗传因素重叠.
需要进一步的研究来验证确定的遗传关联,并探索它们的功能影响.

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