在患有冠状动脉疾病的患者中,宁-1的高血度
Yoshimi Kishimoto1, Emi Saita2, Reiko Ohmori3
1Department of Food Science and Human Nutrition, Setsunan University, Osaka, Japan.
Heart and vessels
|August 15, 2023
概括
在患有冠状动脉疾病 (CAD) 的患者中,血瓦宁-1 (VNN1) 度升高. 较高的VNN1水平与CAD严重程度相关,这表明VNN1是动脉样硬化的潜在生物标志物.
科学领域:
- 生物化学 生化学
- 心血管医学 心血管医学
- 生物标志物 生物标志物
背景情况:
- 瓦宁-1 (VNN1) 是一种与氧化应激和炎症相关的酶,它在动物模型中加速动脉样硬化.
- 之前的研究没有报告冠状动脉疾病 (CAD) 患者的血VNN1度.
研究的目的:
- 这项研究旨在检查疑似CAD冠状动脉血管造影的患者的血VNN1度.
- 为了确定VNN1水平是否与CAD的存在和严重程度有关.
主要方法:
- 在388名接受选择性冠状动脉血管造影的患者中测量了血VNN1度.
- 患者根据CAD的缺席或存在 (1-血管,2-血管或3-血管疾病) 进行了分类.
- 使用统计分析,包括多变量分析,来评估VNN1水平与CAD之间的关联.
主要成果:
- 血VNN1度在患有CAD的患者中明显高于没有CAD的患者 (0.59vs0.46ng/mL).
- 随着CAD严重程度的增加,VNN1水平增加,在患有三血管疾病 (0.61 ng/mL) 的患者中最高.
- 高VNN1度 (>0.48 ng/mL) 是CAD的显著独立预测因子 (OR=1.63).
结论:
- 在患有CAD的患者中,血VNN1度升高.
- VNN1水平与冠状动脉疾病的存在和严重程度有关.
- VNN1可以作为CAD的有价值的生物标志物.
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