[关于儿童阻塞性睡眠呼吸暂停综合征对认知和大脑功能影响的研究进展]
Yu-Lin Wang1,2, Jing-Qi Yang1,2, De-Bo Dong1,2,3
1Sleep and Neuroimaging Center, Faculty of Psychology, Southwest University, Chongqing 400715, China.
Sheng li xue bao : [Acta physiologica Sinica]
|August 16, 2023
概括
儿科阻塞性睡眠呼吸暂停综合征 (OSAS) 可以损害大脑发育和认知功能. 未来的研究应该使用神经成像来了解大脑网络的变化及其与OSAS儿童认知缺陷的联系.
科学领域:
- 神经科学是一个神经科学.
- 儿科医学 儿科医学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 是一种常见的儿童睡眠障碍,导致呼吸道阻塞,导致间歇性缺氧和睡眠碎片化.
- 儿科OSAS的这些生理变化可能会对大脑发育和认知功能产生负面影响,包括执行功能.
- 现有研究强调灰色和白质异常以及OSAS儿童的区域大脑活动变化,但网络层面的影响仍然不清楚.
研究的目的:
- 审查当前对小儿OSAS大脑变化的理解.
- 提出未来的研究方向,重点关注大脑网络组织及其与认知功能的关系.
- 为了确定潜在的神经成像生物标志物用于诊断和治疗监测.
主要方法:
- 对儿科OSAS和神经成像研究 (MRI,EEG) 的现有文献的综述.
- 分析与大脑结构,功能和认知表现相关的发现.
- 综合证据,提出未来的研究途径.
主要成果:
- 以前的研究表明,在患有OSAS的儿童中,大脑损伤和功能缺陷普遍存在.
- 目前的研究主要集中在区域大脑活动上,没有探索网络层面的机制.
- 结构性/功能性大脑变化与儿科OSAS认知障碍之间的关联需要进一步调查.
结论:
- 未来的研究应该使用多模式神经成像来研究小儿OSAS中大脑网络组织的改变.
- 探索大脑网络变化和认知功能障碍之间的关系对于理解OSAS的影响至关重要.
- 识别神经成像生物标志物可以帮助监测大脑发育,临床诊断,并为儿科OSAS开发有效的干预措施.
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