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在不平衡的细胞传感中,普遍的能量精度权衡
Sarah E Harvey1, Subhaneil Lahiri1, Surya Ganguli1
1Department of Applied Physics, Stanford University, Stanford, California 94305, USA.
Physical review. E
|August 16, 2023
概括
这项研究揭示了细胞感知精度的基本限制. 非平衡受体可以通过消耗能量来实现高精度,为生物传感建立热力学不确定性关系.
科学领域:
- 生物物理学的生物物理.
- 统计力学 统计力学
- 信息理论 信息理论
背景情况:
- 单细胞受体对于感知外部度至关重要.
- 之前的模型,如Berg-Purcell极限,建立了传感基准.
- 了解细胞感应的热力学约束是至关重要的.
研究的目的:
- 推导单细胞受体度估计准确性的基本限制.
- 调查能量消耗对简单观察者的受体准确性的作用.
- 在传感精度和能源支出之间建立帕雷托最佳权衡.
主要方法:
- 结合了随机热力学,大偏差理论和信息理论.
- 分析受体状态轨迹和绑定分数测量.
- 导出精度-能量权衡的明确公式.
主要成果:
- 对于理想的观察者来说,没有平衡受体能胜过两种状态的平衡受体.
- 对非平衡受体的基本准确度限制是由能量消耗的函数推导出来的.
- 精度和能量之间的帕雷托最佳权衡可以通过特定的受体设计来实现,例如不均的环.
结论:
- 非平衡的细胞传感受到能源消耗的限制.
- 这项研究将Berg-Purcell极限推广到多个维度.
- 这项工作为物理系统状态持续时间提供了热力学不确定性关系.
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