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在老鼠中,反射排空发生在一致的膀体积下,无论压力或输液速率如何
Daniel J Jaskowak1, Zachary C Danziger1
1Department of Biomedical Engineering, Florida International University, Miami, Florida, USA.
Neurourology and urodynamics
|August 16, 2023
概括
中枢神经系统 (CNS) 解释膀体积触发排尿反射和膀压力激活守护反射,澄清下尿道反射机制.
科学领域:
- 神经科学是一个神经科学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 身体生理学 身体生理学
背景情况:
- 中枢神经系统 (CNS) 通过感官附带来控制下泌尿道反射.
- 中枢神经系统调节这些反射的确切机制尚未完全理解.
研究的目的:
- 调查中枢神经系统测量什么参数 (压力或体积) 激活保护和反应.
- 阐明中枢神经系统在调节下泌尿道功能的作用.
主要方法:
- 开放式出口囊泡测量是在麻醉后的雌性斯普拉格·道利大鼠身上进行的.
- 膀压力和外部尿道关节电肌图测量了10个输液速率 (0.92-65.5毫升/小时).
- 确定了排尿和守护反射的开始,并计算了反射开始时的膀体积.
主要成果:
- 排尿反射在输液速率相似的膀体积下启动,但在输液速率较高时,开始压力增加.
- 护卫反射在输液速率相似的膀压力下启动,但随着输液速率的提高,发病体积下降.
- 膀体积容量增加,但在一些囊泡测量图中没有显著的压力增加.
结论:
- 中枢神经系统似乎解释了膀体积,激活了排尿反射.
- 中枢神经系统似乎解释膀压力激活保护反射.
- 这些发现提供了关于尿路反射背后的感觉处理的见解.
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