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不确定的甲状腺结节与老鼠肉瘤突变的组织学结果:一个案例系列
MacKenzie Jones1, Dorbin G Abendano2, Matthew Turner1
1Medical University of South Carolina College of Medicine, Charleston, South Carolina, USA.
Diagnostic cytopathology
|August 16, 2023
概括
分子测试有助于确定不确定的甲状腺结节. 在这些结节中常见的RAS突变显示有28%的恶性瘤或NIFTP率,HRAS突变表明风险更高.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
背景情况:
- 分子测试提炼了不确定的甲状腺细针愿望.
- 某些突变,如老鼠肉瘤 (RAS) 点突变,与恶性瘤 (ROM) 风险相关,但也出现在良性疾病中.
- 了解RAS突变结核的组织学结果对于患者管理至关重要.
研究的目的:
- 描述带有RAS突变的不确定的甲状腺结节的组织学结果.
- 评估与特定RAS突变 (NRAS,KRAS,HRAS) 相关的恶性瘤风险.
主要方法:
- 贝塞斯达III和IV甲状腺结节与ThyroSeq识别的RAS突变 (NRAS,KRAS,HRAS) 的回顾性分析.
- 收集的数据包括患者特征,分子结果和外科诊断.
- 分析了12个结节的随访数据.
主要成果:
- 确定了18个RAS突变结节;NRAS是最常见的.
- 发现了两种恶性 (卵泡癌,乳头甲状腺癌) 和三种具有乳头样核特征 (NIFTP) 的非侵入性卵泡甲状腺瘤.
- 28%的RAS突变结节是恶性或NIFTP;所有三个HRAS突变结节都是恶性或NIFTP.
结论:
- 不确定的甲状腺结核中的RAS突变具有恶性瘤或NIFTP (28%) 的显著风险.
- HRAS突变似乎具有更高的风险.
- 在这个队列中,孤立的RAS突变与良性结局有关.
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