下萨克森州的地表水:一种多药耐药的Enterobacterales的水库
Cansu Cimen1,2, Janina Noster1, Yvonne Stelzer1
1Institute for Medical Microbiology and Virology, University of Oldenburg, Oldenburg, Germany.
One health (Amsterdam, Netherlands)
|August 16, 2023
概括
在德国的地表水域中发现了多种耐药细菌,包括扩展谱β-乳酸酶和碳酶生成的肠杆菌 (ESBL-E和CPE). 这突出了水生环境作为传播抗生素耐药性的潜在来源.
科学领域:
- 环境微生物学环境微生物学
- 分子生物学分子生物学
- 公共卫生 公共卫生
背景情况:
- 扩展光谱β-乳酸酶和碳酶产生肠道细菌 (ESBL-E和CPE) 由于抗生素耐药性增加,对公众健康构成重大威胁.
- 水生环境被认为是抗微生物药物耐药性基因和耐药细菌的潜在储和传播途径.
研究的目的:
- 调查ESBL-E和CPE在德国下萨克森的地表水体中的发生和特征.
- 评估这些水生环境在多药耐药细菌传播中的潜在作用.
主要方法:
- 从德国下萨克森州的河流,农场附近的水道和游泳湖泊收集地表水样.
- 使用选择性培养介质和表型检测,隔离和识别ESBL-E和CPE.
- 所有分离物的全基因组测序以确定物种,耐药性基因和遗传相关性.
主要成果:
- 在16%的分析水体中检测到多药耐药性肠道细菌.
- 发现的常见物种包括大肠杆菌,Enterobacter cloacae复合体,Citrobacter freundii,Citrobacter braakii和Klebsiella pneumoniae等.
- 显著比例的分离物表现出对第三代化素 (62%) 和卡巴胺 (38%) 的耐药性,并确定了像blaKPC-2,blaVIM-1,blaOXA-181和mcr-9这样的特定耐药性基因.
结论:
- 在德国北部的地表水域中,产生AMpC的肠杆菌,ESBL-E和CPE的存在令人担忧.
- 水生环境是传播多药耐药细菌和相关耐药基因的潜在来源和途径.
- 对水生生态系统的监测和管理策略对于缓解抗生素耐药性的传播至关重要.
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