印度贫困儿童和患有1型糖尿病的青少年的营养状况 - 一项多中心研究
Anuradha V Khadilkar1,2, Chirantap Oza1, Shruti A Mondkar1
1Department of Growth and Endocrinology, Hirabai Cowasji Jehangir Medical Research Institute, Pune, Maharashtra, Odisha, India.
1型糖尿病 (T1D) 影响了许多印度儿童. 这项研究发现,约有五分之一的T1D年轻人超重或肥胖,四分之一的年轻人发育迟缓,强调需要密切监测生长和营养.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 公共卫生 营养 公共卫生 营养
背景情况:
- 印度在20岁以下的儿童中患有1型糖尿病 (T1D) 的全球负担最高.
- 有限的数据存在于贫困的印度儿童T1D的人体状况.
- 加上营养不良,肥胖率的上升也带来了双重负担,可能会导致该群体的胰岛素抵抗.
研究的目的:
- 确定印度儿童和青少年患T1D的营养不良,包括营养不良和超重/肥胖的患病率.
- 确定与这个人口群体中矮身相关的关键因素.
- 分析T1D管理 (持续时间,胰岛素疗法,血糖控制) 与人类测量结果之间的关系.
主要方法:
- 基于注册表的横截面分析使用来自印度各地儿童糖尿病变化 (CDiC) 计划的数据进行.
- 从患有T1D的参与者那里收集了人类测量和临床数据.
- 进行了统计分析,以确定矮身的预测因素,并根据胰岛素治疗方案比较结果.
主要成果:
- 6.4%的参与者营养不良 (3.4%严重),17.7%的人超重/肥胖 (13.2%超重).
- 21.2%的人表现出矮身,家族矮身占7.4%.
- 较长的T1D持续时间和更高的胰岛素需求是矮身的显著预测因素;血糖控制和胰岛素治疗方案不是显著预测因素.
结论:
- 大约五分之一的印度儿童和青少年患有T1D超重/肥胖,大约四分之一的儿童和青少年发育迟缓.
- 低身高在那些糖尿病持续时间较长,胰岛素需求较高的人群中尤为普遍.
- 对人类参数的持续监测对于优化儿科T1D患者的生长和营养状况至关重要.
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