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慢性脏病中的高血症:可用的治疗策略概述
Davide Costa1, Gemma Patella2, Michele Provenzano3
1Department of Law, Economics and Sociology, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Frontiers in medicine
|August 16, 2023
概括
慢性病 (CKD) 患者的高血症 (HK) 会增加死亡风险. 新的降药物可能允许在慢性病患者中继续使用重要的氨酸- ангиотензин- 阿尔多素系统抑制剂 (RAASi).
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 临床药理学 临床药理学
背景情况:
- 超血症 (HK) 是慢性病 (CKD) 患者的一种严重并发症.
- 血清水平升高 (sKsK) 与末期病,心律失常和死亡率的风险增加有关.
- 由于HK,停止使用氨酸- ангиотензин- 阿尔多斯特系统抑制剂 (RAASi) 会加剧这些风险.
研究的目的:
- 审查非透析CKD (ND CKD) 患者中HK的流行病学,发病原因,病因和分类.
- 概述目前在ND CKD中管理血水平的策略.
- 突出新型低血压剂在优化RAASi治疗中的作用.
主要方法:
- 更新了关于ND CKD患者高卡血量现有文献的叙事综述.
- 对HK对死亡率和病进展的预后影响的分析.
- 评估目前和新兴的治疗策略,以控制.
主要成果:
- 在CKD患者中,HK是不良结果的重要风险因素.
- 由于HK,RAASi疗法经常被中断,尽管它具有心脏-脏保护作用.
- 像帕蒂罗默和环酸盐 (SZC) 这样的新药为慢性HK管理和持续RAASi使用提供了潜力.
结论:
- 对于慢性病患者来说,对HK的有效管理至关重要,以保持RAASi等有益的疗法.
- 帕蒂罗默和SZC代表了治疗HK的进步,可能改善心脏和慢性功能衰竭患者的治疗结果.
- 优化控制策略对于改善NDCKD患者的预后至关重要.
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