运动和体育活动干预措施对多发性硬化症患者的步数和强度水平的影响:随机对照试验的系统审查和元分析
Ellen Christin Arntzen1, Razieh Bidhendi-Yarandi2, Marianne Sivertsen3
1Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.
Frontiers in sports and active living
|August 16, 2023
概括
身体活动和运动干预措施没有显著改善多发性硬化症 (MS) 患者的步数或中度至强度身体活动水平. 建议使用客观措施进行进一步的研究,以了解运动对MS患者的影响.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 运动科学 运动科学
背景情况:
- 减少体力活动是患有多发性硬化症 (MS) 个体面临的重大全球挑战.
- 对身体活动,运动和理疗干预措施的客观测量对于了解它们对多发性硬化症患者的影响至关重要.
- 步数和活动强度是评估MS体能功能的关键指标.
研究的目的:
- 系统地审查和元分析体育活动,运动和物理治疗干预措施对MS患者的步数和体育活动强度的设备测量效应.
- 综合关于旨在增加MS患者体力活动的干预措施有效性的证据.
主要方法:
- 在主要数据库 (PubMed,Scopus,CINAHL,Web of Science) 进行了系统的搜索,直到2023年5月.
- 包括随机临床试验 (RCT) 评估了运动干预措施对MS患者的步数和体力活动强度的有效性.
- 修改后的综合报告试验标准和Cochrane偏差风险工具分别用于质量评估和偏差风险评估.
主要成果:
- 包括8项涉及919名多发性硬化症患者的RCT; 77.8%是女性,平均年龄为49.4岁,BMI为27.7公斤/米2.
- 分析显示,干预组和对照组之间在步数 (SMD:0.19,95% CI: -0.36,0.74) 或中度至强度的体力活动水平上没有显著差异.
- 亚组分析和元回归表明,年龄,BMI,疾病持续时间和EDSS得分并不能显著解释异质性.
结论:
- 目前从这次元分析中获得的证据表明,体育活动干预措施对MS患者的步数或中度至强度体育活动水平没有重大影响.
- 这些发现强调需要更多的研究,使用客观的体力活动测量工具,以更好地评估MS的干预有效性.
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