免疫检查点抑制剂诱导的出血性胃炎
Karthik Mathialagan1, Cheng-Hung Tai2, Samdish Sethi1
1Department of Medicine, Yale-New Haven Health-Bridgeport Hospital, Bridgeport, CT.
ACG case reports journal
|August 16, 2023
概括
免疫检查点抑制剂 (ICI) 通过增强免疫反应来治疗癌症,但可以引起与免疫相关的不良事件. 这一案例突出显示出出血性胃炎是抗编程细胞死亡-1疗法的罕见并发症.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 向细胞毒性T淋巴细胞相关抗原-4,编程细胞死亡-1和编程细胞死亡连接体1以恢复抗瘤免疫力.
- ICI可以破坏周边免疫耐受性,导致与免疫相关的不良事件 (irAEs).
- 虽然常见的IRAE记录得很好,但越来越多的人报告罕见的胃肠道症状.
研究的目的:
- 报告一种罕见的出血性胃炎病例.
- 讨论这种irAE的临床表现和管理.
- 强调认识到与ICI治疗相关的各种irAEs的重要性.
主要方法:
- 关于ICI诱导胃炎的文献综述.
- 临床病例介绍和分析.
- 审查患者的病史,治疗和结果.
主要成果:
- 一名患者在接受抗编程细胞死亡-1抗体 pembrolizumab后发展出出血性胃炎.
- 这种并发症呈现出显著的胃肠道出血.
- 及时诊断和管理对于患者的康复至关重要.
结论:
- 流血性胃炎是一种罕见但严重的与免疫相关的不良事件,与抗编程细胞死亡-1疗法有关.
- 早期识别和干预对于管理ICI诱导的胃肠道毒性至关重要.
- 这一案例强调了需要对ICI治疗的患者中IRE频谱保持警的必要性.
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